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Postdoctoral research position

A postdoctoral research position is available in the laboratory of Dr. Vanja Lazarevic at The Experimental Immunology Branch, The National Cancer Institute.
Our laboratory studies the molecular events that lead to the breakdown of immunological tolerance to self-antigens. These processes are clinically manifested in the development of autoimmune diseases. The focus of our laboratory is to understand at a fundamental level the gene products (with a special emphasis on transcription factors) responsible for generating selftolerance.
Our ultimate aim is to determine how acquired or inherited defects in these checkpoints culminate in autoimmune diseases.
To elucidate the nature of immunological dysregulation that leads to the development of autoimmunity, our lab is specifically focused on the pathogenesis of multiple sclerosis. This is a complex disease in which cells of the immune system attack the protective myelin sheath that wraps around neurons in the brain, spinal cord and optic nerves. Relentless and unchecked immune system activation in the central nervous system (CNS) leads to irreversible neuronal damage and, ultimately, paralysis of affected individuals.
We are actively pursuing the following areas of research:
1. the contribution of T cells and innate immune cells in inducing and propagating neuroinflammation
2. the function of microRNAs in shaping the magnitude and quality of T cell responses during antigenic challenge
3. the main regulatory mechanisms that constrain inflammation in the CNS
4. the effect of an inflammatory response on remyelination and neuroregeneration
We are seeking self-motivated, hard-working and enthusiastic candidates with a Ph.D, M.D. or M.D./Ph.D. with expertise in immunology, molecular biology and biochemistry. Interested candidates should submit a cover letter, CV, and the names and contact information for three references to lazarevicv@mail.nih.gov

Vanja Lazarevic
Experimental Immunology Branch
NCI/NIH
10 Center Drive
Building 10, Rm 5A31/33
Bethesda, MD20892
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